* Non-Clinical Associate Professor/Assistant Professor in Pharmacy (2 posts)
* Salary: HK$626,400 – 968,700 / HK$477,360 –
* Location: Hong Kong
* Applications are invited for appointment as Non-Clinical Associate Professor/Assistant Professor in Pharmacy (2 posts) in the Department of Pharmacology and Pharmacy, from as soon as possible, on a three-year fixed-term basis.
* Pharmacy Manager
* Salary: On application
* Location: Portsmouth, Hampshire
* We are looking for highly motivated pharmacy managers who will make a real difference.
* Pharmacist
* Salary: On application
* Location: Portsmouth, Hampshire
* Full or part-time, you will work alongside the Pharmacy Manager and be accountable for the Pharmacy in their absence.
http://www.pjonline.com/
Monday, August 23, 2010
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
1. J Garthwaite,
2. E Southam,
3. C L Boulton,
4. E B Nielsen,
5. K Schmidt and
6. B Mayer
+ Author Affiliations
1.
Wellcome Research Laboratories, Beckenham, Kent, UK.
Abstract
In brain and other tissues, nitric oxide (NO) operates as a diffusible second messenger that stimulates the soluble form of the guanylyl cylase enzyme and so elicits an accumulation of cGMP in target cells. Inhibitors of NO synthesis have been used to implicate NO in a wide spectrum of physiological and pathophysiological mechanisms in the nervous system and elsewhere. The function of cGMP in most tissues, however, has remained obscure. We have now identified a compound, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), that potently and selectively inhibits NO-stimulated guanylyl cyclase activity. In incubated slices of cerebellum, ODQ reversibly inhibited the NO-dependent cGMP response to glutamate receptor agonists (IC50 approximately nM) but did not affect NO synthase activity. The compound did not affect synaptic glutamate receptor function, as assessed in hippocampal slices, nor did it chemically inactivate NO. ODQ did, however, potentially inhibit cGMP generation in response to NO-donating compounds. An action on NO-stimulated soluble guanylyl cyclase was confirmed in studies with the purified enzyme. ODQ failed to inhibit NO-mediated macrophage toxicity, a phenomenon that is unrelated to cGMP, nor did it affect the activity of particulate guanylyl cyclase or adenylyl cyclase. ODQ is the first inhibitor that acts selectively at the level of a physiological NO "receptor" and, as such, it is likely to prove useful for investigating the function of the cGMP pathway in NO signal transduction.
1. J Garthwaite,
2. E Southam,
3. C L Boulton,
4. E B Nielsen,
5. K Schmidt and
6. B Mayer
+ Author Affiliations
1.
Wellcome Research Laboratories, Beckenham, Kent, UK.
Abstract
In brain and other tissues, nitric oxide (NO) operates as a diffusible second messenger that stimulates the soluble form of the guanylyl cylase enzyme and so elicits an accumulation of cGMP in target cells. Inhibitors of NO synthesis have been used to implicate NO in a wide spectrum of physiological and pathophysiological mechanisms in the nervous system and elsewhere. The function of cGMP in most tissues, however, has remained obscure. We have now identified a compound, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), that potently and selectively inhibits NO-stimulated guanylyl cyclase activity. In incubated slices of cerebellum, ODQ reversibly inhibited the NO-dependent cGMP response to glutamate receptor agonists (IC50 approximately nM) but did not affect NO synthase activity. The compound did not affect synaptic glutamate receptor function, as assessed in hippocampal slices, nor did it chemically inactivate NO. ODQ did, however, potentially inhibit cGMP generation in response to NO-donating compounds. An action on NO-stimulated soluble guanylyl cyclase was confirmed in studies with the purified enzyme. ODQ failed to inhibit NO-mediated macrophage toxicity, a phenomenon that is unrelated to cGMP, nor did it affect the activity of particulate guanylyl cyclase or adenylyl cyclase. ODQ is the first inhibitor that acts selectively at the level of a physiological NO "receptor" and, as such, it is likely to prove useful for investigating the function of the cGMP pathway in NO signal transduction.
Michelle McCarthy and Denise R. Kockler
OUP USA Oxford American Handbooks of Medicine
830 pages
978-0-19-537510-7
Flexicover
04 February 2010
Price: £32.95
This item will be ordered from OUP USA. Items ordered from OUP USA are despatched and charged as soon as we receive them, which is normally within 2 weeks
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The overall goal of clinical pharmacy is to promote the correct and appropriate use of prescription and non-prescription medicinal products and devises and to minimize adverse effects. The Oxford American Handbook of Clinical Pharmacy provides an accessible and easily navigable quick-reference guide for practicing and student pharmacists. It is not just another drug book, but a complete, portable coverage of the pharmacy profession, from high-value scientific and clinical information, such as adverse drug reactions, interactions, and pharmaceutical calculations to professional issues such as ethics, practice management, evidence-based medicine, and research. It covers the main body systems and provides a wealth of practical information required by pharmacists on a day-to-day basis, including many topics not traditionally found in handbooks.
"The amount of information this small book contains is really remarkable...the best portable reference I have come across, with the topics nearly all pharmacists will find useful in their areas of clinical practice." - Doody's Notes
"This is the best protable reference I have come across with the topics that nearly all pharmacists will find useful in their areas of clinical practice" - Patrick J. McDonnell, Temple University School of Pharmacy
1: Adherence
2: Adverse Drug Reactions and Drug Interactions
3: Anaphylaxis
4: Clinical Pharmacy Skills
5: Tips for Professional Conduct
6: Pharmacy Automation
7: Clinical Trials
8: Evidence-based Medicine
9: Herbal Medications
10: Patient Management Issues
11: Pharmaceutical Calculations
12: Pharmaceutical and Patient-Centered Care
13: Medication Management
14: Research
15: Therapy-Related Issues
16: Appendix
Description Reviews Table of Contents
The overall goal of clinical pharmacy is to promote the correct and appropriate use of prescription and non-prescription medicinal products and devises and to minimize adverse effects. The Oxford American Handbook of Clinical Pharmacy provides an accessible and easily navigable quick-reference guide for practicing and student pharmacists. It is not just another drug book, but a complete, portable coverage of the pharmacy profession, from high-value scientific and clinical information, such as adverse drug reactions, interactions, and pharmaceutical calculations to professional issues such as ethics, practice management, evidence-based medicine, and research. It covers the main body systems and provides a wealth of practical information required by pharmacists on a day-to-day basis, including many topics not traditionally found in handbooks.
Friday, August 6, 2010
| Institute Of Pharmacy | |
|---|---|
| Established: | 5th September 1949 |
| Type: | B.Pharm and Diploma College |
| Location: | Jalpaiguri, West Bengal,India |
| Campus: | Urban |
| Affiliations: | West Bengal University of Health Sciences |
History::
The building was a medical School #L.M.F) named Jackson Medical School (Estd in 1932) which was closed by the Government with the abolision of the course. Later on Pharmacy Training Centre subsequently named as Institute Of Pharmacy conferring Licensiatein Pharmacy was established in the said Jackson Medical School on 5 September 1949 and the Diploma in pharmacy (D.Pharm) course was started from the year 1954. Dr. B.C.Roy, the them farsighted Chief Minister of West Bengal realized the importance of modern pharmaceutical science & technology in India hence the first Diploma Pharmacy Institute not only of West Bengal but also of India come into being at Jalpaiguri in the year 1949. In the respect Dr. Roy got full co-operation, help and valuable advice from his beloved student Dr. Charu Chandra Sanyal who was not only an eminent physician but a man with fair knowledge on local medicinal plants set up the college.It is approved by AICTE and PCI.
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